Fig. 3

Quality components resulting from different parameter settings and different datasets. a Effects of varying other_rnf_min (different curves) and sample_mut_freq_min (along the curves) with constant sample_cov_min = 7. The inset contains maximal achievable TPRs for given FPR thresholds with the optimal parameter settings. b Effects of changing sample_cov_min (different curves) and sample_mut_freq_min (along the curves) with fixed other_rnf_min = 0.93. c Effects of varying other_rnf_min (different curves) and the S score parameter (along the curves) with sample_cov_min = 5 and sample_mut_freq_min = 0.21. d Effects of varying the size of the dataset. Measurement points correspond to the parameter settings of the inset of (a). Mean values and standard deviation of three randomly chosen datasets are shown (see Additional file 2). e Effects of decreased sample coverage. Measurement points correspond to the parameter settings of the inset of (a). Mean values and standard deviation of three randomly down-sampled measurements are shown (see Additional file 2)