From: Mixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data
 | Spearman correlation estimate summary statistics: mean (min, max) | ||
---|---|---|---|
Maternal fasting | Maternal 1-hour | Newborn cord serum | |
Not normalized | .33 (.09, .75) | .33 (.09, .62) | .41 (.19, .87) |
Mean centering | .49 (.24, .89) | .51 (.26, .80) | .59 (.35, .94) |
Median scaling | .49 (.25, .87) | .51 (.27, .79) | .59 (.34, .93) |
Quantile | .36 (.13, .79) | .37 (.15, .64) | .45 (.20, .93) |
Quantile + ComBat | .46 (.16, .87) | .46 (.18, .80) | .51 (.24, .95) |
EigenMS | .30 (−.07, .75) | .33 (.08, .61) | .42 (.17, .87) |
VSN | .38 (.08, .85) | .37 (.16, .76) | .47 (.16, .93) |
Batch normalizer | .27 (.11, .70) | .24 (.10, .59) | .25 (.00, .78) |
mixnorm | .52 (.25, .91) | .54 (.28, .82) | .59 (.31, .95) |