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Table 3 The survival time prediction performance (p-value and hazard ratio) for the top 5, top 10 and top 15 significant genes based on concordance index: DEA, dwgLASSO with no prior biological knowledge incorporated: dwgLASSO (no prior), KDDN, and dwgLASSO with prior biological knowledge incorporated: dwgLASSO (prior)

From: Incorporating prior biological knowledge for network-based differential gene expression analysis using differentially weighted graphical LASSO

Methods Top 5 significant genes Top 10 significant genes Top 15 significant genes
  p-value Hazard ratio p-value Hazard ratio p-value Hazard ratio
DEA 0.0073 1.851 2.00E-03 2.037 4.00E-04 2.274
dwgLASSO (no prior) 0.0066 1.864 3.10E-04 2.316 4.60E-06 2.969
KDDN 0.0022 2.028 7.46E-07 3.304 8.04E-06 2.889
dwgLASSO (prior) 0 . 0 0 1 3 2 . 1 0 4 7 . 0 1 E 0 7 3 . 3 2 5 9 . 3 7 E 0 7 3 . 2 5
  1. The best performance is marked in bold when the gene number is fixed