Table 2 (A) Fourteen one-to-one EC-Pfam associations found by ECDomainMiner and involving domains of unknown function, (B) an example of one-to-one EC-Pfam association with very similar EC and Pfam descriptions, and (C) two examples of obligate Pfam pairs associated with an EC number
From: ECDomainMiner: discovering hidden associations between enzyme commission numbers and Pfam domains
EC | Pfam | Score | EC name | Pfam name | Quality | PDBs (SIFTS) | |
|---|---|---|---|---|---|---|---|
A | 2.7.8.28 | PF01933 | 0.972 | 2-phospho-L-lactate transferase | Uncharacterised protein family UPF0052 | Gold | 9/0/11 |
4.1.99.5 | PF11266 | 0.944 | Aldehyde oxygenase (deformylating) | Protein of unknown function DUF3066 | Gold | 18/0/0 | |
2.1.1.286 | PF11968 | 0.889 | 25S rRNA (adenine(2142)-N(1))- methyltransferase | Putative methyltransferase DUF3321 | Gold | 0/0/0 | |
1.13.99.1 | PF05153 | 0.667 | Inositol oxygenase | Family of unknown function DUF706 | Gold | 4/0/0 | |
2.4.1.155 | PF15027 | 0.611 | Alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase | Domain of unknown function DUF4525 | Gold | 0/0/0 | |
4.2.3.130 | PF10776 | 0.611 | Tetraprenyl-beta-curcumene synthase | Protein of unknown function DUF2600 | Gold | 0/0/0 | |
2.3.1.78 | PF07786 | 0.609 | Heparan-alpha-glucosaminide N-acetyltransferase | Protein of unknown function DUF1624 | Gold | 0/0/0 | |
3.1.4.45 | PF09992 | 0.584 | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase | Predicted periplasmic protein DUF2233 | Gold | 0/0/1 | |
1.13.12.20 | PF08592 | 0.556 | Noranthrone monooxygenase | Domain of unknown function DUF1772 | Gold | 0/0/0 | |
2.1.1.312 | PF11312 | 0.556 | 25S rRNA (uracil(2843)-N(3))- methyltransferase. | Protein of unknown function DUF3115 | Gold | 0/0/0 | |
2.1.1.313 | PF10354 | 0.556 | 25S rRNA (uracil(2634)-N(3))- methyltransferase | Domain of unknown function DUF2431 | Gold | 0/0/0 | |
2.5.1.128 | PF01861 | 0.556 | N4-bis(aminopropyl) spermidine synthase | Protein of unknown function DUF43 | Gold | 0/0/1 | |
5.2.1.14 | PF13225 | 0.556 | Beta-carotene isomerase | Domain of unknown function DUF4033 | Gold | 0/0/0 | |
1.14.99.29 | PF04248 | 0.333 | Deoxyhypusine monooxygenase | Domain of unknown function DUF427 | Silver | 0/0/5 | |
B | 6.3.2.25 | PF03133 | 0.610 | Tubulin–tyrosine ligase | Tubulin-tyrosine ligase family | Gold | 0/2/21 |
C | \(2.7.1.30\left \{{\vphantom {\frac {\frac {\frac {1}{1}}{1}}{1}}}\right.\) | PF00370 | 0.847 | Glycerol kinase | FGGY family of carbohydrate kinases, N-terminal domain | Gold | 85/32/9 |
PF02782 | 0.828 | FGGY family of carbohydrate kinases, C-terminal domain | Gold | 85/32/7 | |||
\(6.3.4.23 \left \{{\vphantom {\frac {\frac {\frac {1}{1}}{1}}{1}}}\right.\) | PF06973 | 0.997 | Formate-phosphoribosyl-amino- imidazol | DUF1297 | Gold | 16/3/0 | |
PF06849 | 0.997 | carboxamide ligase | DUF1246 | Gold | 16/3/0 |