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Table 2 (A) Fourteen one-to-one EC-Pfam associations found by ECDomainMiner and involving domains of unknown function, (B) an example of one-to-one EC-Pfam association with very similar EC and Pfam descriptions, and (C) two examples of obligate Pfam pairs associated with an EC number

From: ECDomainMiner: discovering hidden associations between enzyme commission numbers and Pfam domains

  EC Pfam Score EC name Pfam name Quality PDBs (SIFTS)
A 2.7.8.28 PF01933 0.972 2-phospho-L-lactate transferase Uncharacterised protein family UPF0052 Gold 9/0/11
  4.1.99.5 PF11266 0.944 Aldehyde oxygenase (deformylating) Protein of unknown function DUF3066 Gold 18/0/0
  2.1.1.286 PF11968 0.889 25S rRNA (adenine(2142)-N(1))- methyltransferase Putative methyltransferase DUF3321 Gold 0/0/0
  1.13.99.1 PF05153 0.667 Inositol oxygenase Family of unknown function DUF706 Gold 4/0/0
  2.4.1.155 PF15027 0.611 Alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase Domain of unknown function DUF4525 Gold 0/0/0
  4.2.3.130 PF10776 0.611 Tetraprenyl-beta-curcumene synthase Protein of unknown function DUF2600 Gold 0/0/0
  2.3.1.78 PF07786 0.609 Heparan-alpha-glucosaminide N-acetyltransferase Protein of unknown function DUF1624 Gold 0/0/0
  3.1.4.45 PF09992 0.584 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase Predicted periplasmic protein DUF2233 Gold 0/0/1
  1.13.12.20 PF08592 0.556 Noranthrone monooxygenase Domain of unknown function DUF1772 Gold 0/0/0
  2.1.1.312 PF11312 0.556 25S rRNA (uracil(2843)-N(3))- methyltransferase. Protein of unknown function DUF3115 Gold 0/0/0
  2.1.1.313 PF10354 0.556 25S rRNA (uracil(2634)-N(3))- methyltransferase Domain of unknown function DUF2431 Gold 0/0/0
  2.5.1.128 PF01861 0.556 N4-bis(aminopropyl) spermidine synthase Protein of unknown function DUF43 Gold 0/0/1
  5.2.1.14 PF13225 0.556 Beta-carotene isomerase Domain of unknown function DUF4033 Gold 0/0/0
  1.14.99.29 PF04248 0.333 Deoxyhypusine monooxygenase Domain of unknown function DUF427 Silver 0/0/5
B 6.3.2.25 PF03133 0.610 Tubulin–tyrosine ligase Tubulin-tyrosine ligase family Gold 0/2/21
C \(2.7.1.30\left \{{\vphantom {\frac {\frac {\frac {1}{1}}{1}}{1}}}\right.\) PF00370 0.847 Glycerol kinase FGGY family of carbohydrate kinases, N-terminal domain Gold 85/32/9
   PF02782 0.828   FGGY family of carbohydrate kinases, C-terminal domain Gold 85/32/7
  \(6.3.4.23 \left \{{\vphantom {\frac {\frac {\frac {1}{1}}{1}}{1}}}\right.\) PF06973 0.997 Formate-phosphoribosyl-amino- imidazol DUF1297 Gold 16/3/0
   PF06849 0.997 carboxamide ligase DUF1246 Gold 16/3/0
  1. The ‘PDBs (SIFTS)’ column contains 3 counts of PDB chains containing the mentioned Pfam domain and having either the same EC annotation in SIFTS as calculated by ECDomainMiner (first position), or different EC annotations between SIFTS and ECDomainMiner (second position), or no EC annotations in SIFTS (third position). Complete lists of PDB identifiers may be retrieved from the ECDomainMiner web server
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