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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Differential correlation analysis of glioblastoma reveals immune ceRNA interactions predictive of patient survival

Fig. 1

Illustration of miRNA-modulated ceRNA interaction. a Illustration of ceRNA interaction. An increase in the expression of one ceRNA attracts its targeting miRNAs and protects the other ceRNA from miRNA-induced degradation. Such competition leads to coexpression between two ceRNAs in a miRNA-modulated manner. b Based on previous reports and the characteristics of high-throughput profiling, interaction strength between two ceRNAs is optimized within a certain range of miRNA abundance. c Illustration of miRNA-modulated ceRNA interaction. We devised a ceRNA inference by differential correlation analysis (CEIDCA) to identify miRNA-modulated ceRNA interaction pairs. For each putative ceRNA triplet, CEIDCA partitions samples based on miRNA expression levels and statistically infers whether the two ceRNAs are differentially correlated in one group compared to another

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BMC Bioinformatics

ISSN: 1471-2105

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