Fig. 1

Representatives of the five fold classes in our test set CATH2833. The arc repressor mutant, subunit A fold (CATH 1.10.10) is a common orthogonal helix bundle, found, for example, in the Zb domain from the RNA editing human enzyme ADAR1 (CATH code 1xmkA00). The immunoglobulin-like fold is a β sandwich, found in many immunoglobulin-like proteins, such as the human MCG protein (CATH code 4unuA00). The TIM barrel is a very common α/β fold, shown in an isomerase of the parasite Leishmania mexicana (CATH code 2vxnA00). The α−β plait fold is a two-layer sandwich, shown here in a human nucleoprotein, HNRNP (CATH code 1l3kA01). The Rossmann fold is a very common three-layer sandwich fold in the mixed α−β class, found, for example, in the D-amino acic oxydase from Rhodotorula toruloides (CATH code 1c0pA01). All images were generated using Pymol http://www.pymol.org