Fig. 6
From: Avoiding the pitfalls of gene set enrichment analysis with SetRank
The principle of sample source bias. The black bar represents the group of genes that are not expressed in any sample analysed. The gradient-filled bar represents the set of genes expressed in at least one sample, ordered by significance of differential expression between the different conditions tested. The inset box marked “sample-specific gene set” denotes a gene set that contains genes that are evenly distributed among all significance values of the expressed genes; the one marked “treatment-specific” gene set is highly enriched in significant differentially expressed genes. Note that the box size does not reflect the gene set size but merely the range of significance values of its genes