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Table 2 Predicted bacterial interactome sizes

From: Bacterial protein meta-interactomes predict cross-species interactions and protein function

  Predicted interactomeb size from …  
Species and Strain Name Meta-interactome (this study) Published interactomea Meta-interactome, in PPIsa Meta-interactome (experimental PPI only), in PPIsa Proteins in proteome (vs. proteins in meta-interactome)
Bacillus subtilis str. 168 17146 N/A 117229 67921 4175 (1597)
Caulobacter crescentus CB15 25792 N/A 177318 1580788 3885 (1482)
Escherichia coli K-12 43702 25736 62770 30087 4306 (3593)
Helicobacter pylori 26695 10576 13275 14271 5455 1553 (1337)
Mesorhizobium loti MAFF303099 57905 50735 256414 50838 7272 (3456)
Mycoplasma genitalium G37 718 N/A 7331 N/A 475 (149)
Pseudomonas aeruginosa PAO1 47815 N/A 88143 7073281 5892 (2488)
Salmonella enterica subsp. enterica serovar Typhi 30788 N/A 268219 554147 4607 (2723)
Staphylococcus aureus NCTC 8325 9339 N/A 59233 650299 2767 (1099)
Synechocystis sp. PCC 6803 27816 11221 66575 11811 3575 (2311)
Treponema pallidum str. Nichols 6722 7433 10350 7762 1036 (835)
  1. aMethod of Stumpf et al. [7]
  2. bPublished interactomes are those specified in Table 1
  3. The interactome size prediction methods in this study are the results of predicting that two different orthologous group members will interact as long as members of the two groups have been observed interacting in any bacterial species. The resulting totals are shown in the second column (Predicted interactome size from meta-interactome (this study)). Results from the interactome size prediction method used by Stumpf et al. [7] are shown here for comparison: where possible, these are used with interaction and interactor totals from published interactomes (third column). Two hybrid approaches are also presented, with the input for the Stumpf method provided by the total counts of interactors and interactions predicted by the interactome (fourth column) or by the experimentally-observed interactions in the meta-interactome only (fifth column). The final column provides the count of proteins in each respective proteome along with the fraction of those proteins present in the meta-interactome, including all proteins involved in functional predictions