Fig. 3
From: MOST: most-similar ligand based approach to target prediction
Predicting novel targets for the drug fluanisone by MOST with FDR control. a, scheme of integrating MOST with FDR control procedure. b, the structure of fluanisone. c, the distribution of p value of predicted targets, which was generated by searching fluanisone against 1,439 human targets via MOST. d, top 5 hits of target prediction for fluanisone. Two novel targets of fluanisone, adrenoceptor alpha 1B (ADRA1B) and adrenoceptor alpha 1D (ADRA1D), were characterized by reference (Keiser et al. [7]) but not CHEMBL database. The adjusted p values were calculated by Benjamini-Hochberg algorithm. e, the inference process of fluanisone novel targets by MOST. Fluanisone was found to be similar (Tc = 0.70) to compound CHEMBL8618, which potently acts on ADRA1B and ADRA1D. They were assigned small p values by MOST