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Table 2 Demographic, clinical and pathologic features of colorectal cancers in the network analysis dataset by tumor location

From: Biomarker correlation network in colorectal carcinoma by tumor anatomic location

  Total (n = 1380) Proximal colon cancer (n = 690) Distal colorectal cancer (n = 690) P valuea
Age, mean (SD) 69.9 (8.6) 70.0 (8.8) 69.7 (8.5) 0.56
Sex
 Female 758 (54.9%) 379 (54.9%) 379 (54.9%) 0.99
 Male 622 (45.1%) 311 (45.1%) 311 (45.1%)
Tumor location
 Cecum 253 (18.3%) 253 (36.7%) 0 (0%) <0.0001
 Ascending colon 303 (22.0%) 303 (43.9%) 0 (0%)
 Hepatic flexure 45 (3.3%) 45 (6.5%) 0 (0%)
 Transverse colon 89 (6.4%) 89 (12.9%) 0 (0%)
 Splenic flexure 31 (2.2%) 0 (0%) 31 (4.5%)
 Descending colon 66 (4.8%) 0 (0%) 66 (9.6%)
 Sigmoid colon 296 (21.4%) 0 (0%) 296 (42.9%)
 Rectosigmoid junction 100 (7.2%) 0 (0%) 100 (14.5%)
 Rectum 197 (14.3%) 0 (0%) 197 (28.6%)
TNM Stage
 I 324 (26.2%) 146 (22.9%) 178 (29.7%) 0.002
 II 404 (32.7%) 232 (36.4%) 172 (28.7%)
 III 332 (26.8%) 159 (24.9%) 173 (28.9%)
 IV 177 (14.3%) 101 (15.8%) 76 (12.7%)
Tumor differentiation
 Well to moderate 1231 (89.2%) 577 (83.6%) 654 (94.8%) <0.0001
 Poor 149 (10.8%) 113 (16.4%) 36 (5.2%)
Family history of colorectal cancer in first-degree relative(s)
 No 1074 (78.4%) 532 (77.9%) 542 (78.9%) 0.65
 Yes 296 (21.6%) 151 (22.1%) 145 (21.1%)
  1. The % numbers indicate the fraction of cases with a given feature among total cases, proximal colon cancer cases, or distal colorectal cancer cases
  2. a P value was calculated using a t-test for age and chi-squared tests for categorical variables