Fig. 12

Effect of duration of growth-based screens on performance. Screens were simulated for a set of genes in which 10% of all genes had negative phenotypes (less fit than wild type). Simulations were carried out for screens with different durations, as measured by the number of passages, and for different representations at the transfection, bottleneck and sequencing stages. Metrics for signal, noise, and signal-to-noise ratio are defined in the Implementation section. Lines and light margins represent means and 95% confidence intervals, respectively, for 25 independent simulation runs