Fig. 8
From: CRISPulator: a discrete simulation tool for pooled genetic screens
Importance of representation of library elements at different stages of the screen. CRISPulator simulations reveal the effect of library representation at different screen stages (Transfection, bottlenecks, sequencing) on hit detection. Simulations were run for FACS-based screens (top row) and growth-based screens (bottom row). Lines and light margins represent means and 95% confidence intervals, respectively, for 10 independent simulation runs