Fig. 2

Venn diagram with the different metabolite categories in the network reconstruction. Metabolites M: all metabolites in the network; metabolite pool E _m : metabolites considered available from start; start metabolites: all metabolites in the model contained in arcs with a molecular mass between 0 and 300; basis metabolites: expert-curated subset of start metabolites; cofactors: cofactors for enzymes; excluded metabolites: treated as cofactors; external metabolites: not contained in the metabolite pool, cannot be externally supplied; generic metabolites: marked as ’generic’ in their KEGG entry; the light red background indicates the set that can contain the product P