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Table 10 The result of interactome analysis for Pfam candidate domains in different cancer types

From: Cancerouspdomains: comprehensive analysis of cancer type-specific recurrent somatic mutations in proteins and domains

Cancer type Pfam specific proteins Proteins with Pfam candidate domain
#Nodes #Edges Expected number of edges PPI enrichment p-value Significant or Not #Nodes #Edges Expected number of edges PPI enrichment p-value Significant or Not
BRCA 16 14 5 0.002 YES      
COAD 7 1 0 0.04 YES      
GBM 8 1 0 0.126 NO 471 2687 558 0 YES
KIRC 156 40 16 4E-07 YES      
KIRP 43 30 3 0 YES      
LGG 14 2 0 7E-04 YES      
LUAD 247 282 9 0 YES      
OV 6 0 0 1 NO 186 3 1 0.0738 NO
UCEC 16 1 0 7E-04 YES      
ACC 46 3 1 0.069 NO 319 113 14 0 YES
BLCA 64 14 2 1E-07 YES      
CHOL 21 4 0 2E-04 YES      
ESCA 5 1 0 0.002 YES      
HNSC 42 25 1 0 YES      
KICH 23 1 2 0.79 NO 198 105 33 0 YES
LIHC 9 1 0 0.016 YES      
LUSC 8 0 0 1 NO 1132 9242 2583 0 YES
PAAD 151 59 21 6E-12 YES      
PCPG 43 5 1 0.01 YES      
PRAD 20 7 1 2E-06 YES      
READ 17 4 0 1E-04 YES      
SARC 11 3 0 2E-05 YES      
SKCM 25 22 4 7E-11 YES      
STAD 35 69 1 0 YES      
TGCT 42 8 1 3E-06 YES      
THCA 19 1 0 0.149 NO 301 132 29 0 YES
THYM 5 0 0 1 NO 40 32 0 0 YES
UCS 26 1 1 0.462 NO 55 45 8 0 YES
UVM 34 3 3 0.609 NO 98 22 14 0.039 YES
Pan-cancer 312 231 34 0 YES