Cancerouspdomains: comprehensive analysis of cancer type-specific recurrent somatic mutations in proteins and domains

Table 10 The result of interactome analysis for Pfam candidate domains in different cancer types

Cancer type	Pfam specific proteins					Proteins with Pfam candidate domain
Cancer type	#Nodes	#Edges	Expected number of edges	PPI enrichment p-value	Significant or Not	#Nodes	#Edges	Expected number of edges	PPI enrichment p-value	Significant or Not
BRCA	16	14	5	0.002	YES
COAD	7	1	0	0.04	YES
GBM	8	1	0	0.126	NO	471	2687	558	0	YES
KIRC	156	40	16	4E-07	YES
KIRP	43	30	3	0	YES
LGG	14	2	0	7E-04	YES
LUAD	247	282	9	0	YES
OV	6	0	0	1	NO	186	3	1	0.0738	NO
UCEC	16	1	0	7E-04	YES
ACC	46	3	1	0.069	NO	319	113	14	0	YES
BLCA	64	14	2	1E-07	YES
CHOL	21	4	0	2E-04	YES
ESCA	5	1	0	0.002	YES
HNSC	42	25	1	0	YES
KICH	23	1	2	0.79	NO	198	105	33	0	YES
LIHC	9	1	0	0.016	YES
LUSC	8	0	0	1	NO	1132	9242	2583	0	YES
PAAD	151	59	21	6E-12	YES
PCPG	43	5	1	0.01	YES
PRAD	20	7	1	2E-06	YES
READ	17	4	0	1E-04	YES
SARC	11	3	0	2E-05	YES
SKCM	25	22	4	7E-11	YES
STAD	35	69	1	0	YES
TGCT	42	8	1	3E-06	YES
THCA	19	1	0	0.149	NO	301	132	29	0	YES
THYM	5	0	0	1	NO	40	32	0	0	YES
UCS	26	1	1	0.462	NO	55	45	8	0	YES
UVM	34	3	3	0.609	NO	98	22	14	0.039	YES
Pan-cancer	312	231	34	0	YES

ISSN: 1471-2105