Fig. 6

Volumetric reconstructions of multiple neocortical circuits with solid voxelization. The presented workflow is capable of creating large scale volumetric models for circuits with different complexity. a Single cell volume. b A group of five pyramidal neurons. c 5% of the pyramidal neurons that exist in layer five in the neocortical column. d 5% of all the neurons in a single column (containing ∼31,000 neurons). e A uniformly-sampled selection of only 1% of the neurons in a digital slice composed of seven columns (containing ∼210,000 neurons) stacked together. The resolution of the largest dimension of each volume is set to 8000 voxels. The area covered by the orange box in (e) represents the maximum volumetric extent that could be simulated in similar previous studies [28, 29]