Table 3 Summary of accessibility and topological parameters computed by VERMONT for mutations (nsSNPs) in the p53 (PDBid 1TSR) core domain that were experimentally characterized
From: Vermont: a multi-perspective visual interactive platform for mutational analysis
| Â | Accessibility | Degree | Closeness (E-04) | Betweenness | ||||
|---|---|---|---|---|---|---|---|---|
|  | μ | σ | μ | σ | μ | σ | μ | σ |
Arg273His | 30.60 | 6.53 | 6.68 | 1.10 | 9.69 | 1.64 | 1487.24 | 567.77 |
Gly245Ser | 8.81 | 6.97 | 2.91 | 0.60 | 7.77 | 1.38 | 225.21 | 113.30 |
Arg249Ser | 15.46 | 4.38 | 5.30 | 1.13 | 8.66 | 1.48 | 635.93 | 286.51 |
Arg248Ala | 72.98 | 8.74 | 3.13 | 0.47 | 8.22 | 1.41 | 335.64 | 263.27 |
Cys242Ser | 13.82 | 7.24 | 3.31 | 0.73 | 7.37 | 1.18 | 200.86 | 130.92 |
His168Arg | 26.46 | 4.59 | 5.86 | 0.83 | 8.57 | 1.42 | 799.43 | 267.57 |
Val143Ala | 0.31 | 0.55 | 4.00 | 0.46 | 9.55 | 1.69 | 642.42 | 407.30 |
Ile195Thr | 5.76 | 0.70 | 3.88 | 0.70 | 10.51 | 2.06 | 1193.47 | 455.24 |