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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Development of models for predicting Torsade de Pointes cardiac arrhythmias using perceptron neural networks

Fig. 1

Schematic changes in ventricular action potential at the molecular level within the cardiomyocytes. The resting membrane potential of cardiomyocytes is about −90 mV (mV) while at the full depolarization it can be gradually shifted to +20 mV. In the repolarization stage, membrane potential will return to −90 mV. Some drugs can prolong the duration of normal action potential (lengthened action potential in green) which eventually can lead to drug-induced arrhythmia. Consequently, production of lengthened action potential (long QT syndrome) may initiate TdP arrhythmia (Adapted with permission from [31])

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BMC Bioinformatics

ISSN: 1471-2105

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