Fig. 10

Results on sample GBM 10. The chromosomes were divided into segments according to the breakpoints inferred from the paired ends reads data and were named a-l. Segment sizes are not shown to scale. We mark interval, reference and bridge edges by black, dotted and red arcs respectively. The number next to a red edge (bridge) is the number of observed supporting reads for that bridge. In all subfigures the same intervals (here: a through l for Chr. 4 and a, b for Chr. X) are aligned. The numbers in the second line are observed coverage values. a Bridge graph for chromosomes X and 4. The bridge bteween segments k and l is a result of breakpoint filtering (see Additional file 8). b Solution suggested by our algorithm. For this sample the average distance of the resulting karyotype from the data, weighted by segment length, is 0.28. Note that segments a, c, d, and h have edges in both directions suggesting the solution includes traversal of these segments in both directions. c The different paths comprising the solution, representing the rearranged karyotype of chromosomes 4 and X