Table 1 A gene set differentially co-expressed by p53-mutational status (p-value = 2.75E-231 and coefficient = 1.137) only and insignificant for the other co-factors: coefficients/p-values for ER and Grade are 0.087/0.114 and −0.063/0.028 respectively. Co-expression of the set occurs in p53 mutated tumors only. ER dependent differential expression, ER binding sites and p53 binding sites are also given for the geneset
From: MultiDCoX: Multi-factor analysis of differential co-expression
No. | Gene | ER (DE) | ER Binding Site | p53 Binding Site | Gene Description |
|---|---|---|---|---|---|
1. | GFRA1 | Yes (up) | Yes (dist = 58.5 kb) | No | TGF-beta related neurotrophic factor receptor |
2. | FOXA1 | No | Yes (dist = 4.79 kb) | No | Forkhead box protein A1 |
3. | GATA3 | No | Yes (dist = 30.33 kb) | Yes | GATA binding protein 3 |
4. | SPDEF | No | Yes (dist = 1.15 kb) | No | SAM pointed domain containing ets transcription factor |
5. | ESR1 | Yes (up) | Yes (dist = 32.24 kb) | Yes | Estrogen receptor 1 |
6. | GAMT | No | dist >100Â kb | Yes | guanidinoacetate N- methyltransferase |
7. | TOX3 | No | dist >100Â kb | No | TOX high mobility group box family member 3 |
8. | AGR3 | Yes (up) | Yes (dist = 54.06 kb) | No | anterior gradient 3 homolog (Xenopus laevis) |
9. | SDR16C5 | No | dist >100Â kb | No | Short-chain dehydrogenase/reductase family 16C member 5 |
10. | PIP | No | dist >100Â kb | No | prolactin-induced protein |
11. | CYP2B7P1 | No | dist >100Â kb | No | cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene 1 |
12. | SYTL5 | Yes (up) | Yes (dist = 94.21 kb) | No | synaptotagmin-like protein 5 |
13. | MKX | No | Yes (dist = 35.21 kb) | No | mohawk homeobox |
14. | REEP6 | No | dist >100Â kb | No | receptor accessory protein 6 |
15. | AGR2 | Yes (up) | Yes (dist = 2.15 kb) | No | anterior gradient 2 homolog (Xenopus laevis) |
16. | ANKRD30A | No | dist >100Â kb | No | ankyrin repeat domain 30A |
17. | CA12 | Yes (up) | Yes (dist = 56.69 kb) | Yes | Carbonate dehydratase XII |
18. | SCGB2A1 | No | dist >100Â kb | No | secretoglobin, family 2A, member 1 |