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Fig. 5 | BMC Bioinformatics

Fig. 5

From: An integrated meta-analysis approach to identifying medications with potential to alter breast cancer risk through connectivity mapping

Fig. 5

The Volcano plot of differential gene expression tumor vs adjacent normal comparison. Genes are plotted in different colors depending their passes of the following filters. Filter 1: the differential expression of gene is statistically significant, ie. p-valve < 1/22277, across all 50 runs; Filter 2: The absolute value of the average log2 fold change across the 50 runs is greater than 2; Filter 3: The average expression level of tumor group or normal group is greater than 6. Green spots represent genes that have passed all the 3 filters and been selected into the gene signature; Black spots represent genes that did not pass filter 1; Red: genes that passed filter 1 but not filter 2; Orange spots are genes that passed filter 1 and 2, but not filter 3

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BMC Bioinformatics

ISSN: 1471-2105

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