Fig. 3

Network analysis for the identification of potential transdifferentiation factors. a, b Graphs showing the connection between transcription factors differentially expressed between fibroblasts and ES cells. 3a is an undirected graph showing the protein-protein interaction relationship based on the STRING database, and 3b is constructed based on the Regnetwork repository, showing the regulatory relationship. The size of the nodes and the color gradient indicate the log fold change of the genes. The graphs have been zoomed in to only include the genes with large LFC and small p-value. c Predicted transdifferentiation factor lists based on the network score ranking. The table includes information such as the center transcription factor score, the total number of vertices in its direct neighborhood, and the number of activated neighbors with gene score above a user-specified threshold. Clicking entries on the table will plot the local neighborhood network centered on that TF