From: Evaluation and comparison of bioinformatic tools for the enrichment analysis of metabolomics data
Tool | Data | Rank | Total metab. | Hits | P-value | Adjusted p-value |
---|---|---|---|---|---|---|
Reactome | ||||||
 Metabolism of amino acids and derivates | ||||||
  ConsensusPathDB | Real | 3 | 272 | 18 | 8.46E-14 | 4.55E-12 |
Enriched | 1 | 272 | 12 | 7.67E-15 | 5.75E-13 | |
  IMPaLA | Real | 3 | 272 | 18 | 8.46E-14 | 4.21E-11 |
Enriched | 1 | 272 | 12 | 7.67E-15 | 1.02E-11 | |
  PathVisio | Real | NA | NA | NA | NA | NA |
Enriched | NA | NA | NA | NA | NA | |
  Reactome | Real | 9 | 283 | 18 | 1.03E-04 | 3.81E-03 |
Enriched | 1 | 283 | 12 | 8.18E-08 | 1.00E-05 | |
HumanCyc | ||||||
 tRNA charging | ||||||
  ConsensusPathDB | Real | 2 | 24 | 8 | 9.14E-12 | 1.92E-10 |
Enriched | 2 | 24 | 5 | 4.40E-09 | 1.30E-07 | |
  HumanCyc | Real | 8 | 24 | 8 | 2.57E-05 | 0.002 |
Enriched | 18 | 24 | 5 | 7.90E-05 | 4.25E-03 | |
  IMPaLA | Real | 2 | 24 | 8 | 9.14E-12 | 2.28E-09 |
Enriched | 2 | 24 | 5 | 4.40E-09 | 3.51E-07 | |
  MBRole (full database) | Real | 4 | 64 | 8 | 8.38E-09 | 1.14E-06 |
Enriched | 47 | 64 | 4 | 3.58E-07 | 7.97E-06 | |
  MBRole (Homo sapiens) | Real | 5 | 64 | 8 | 1.26E-04 | 2.44E-03 |
Enriched | 11 | 64 | 5 | 1.58E-04 | 1.52E-03 | |
  MetExplore | Real | 1 | NA | 8 | 7.11E-07 | 7.75E-05 |
Enriched | 6 | NA | 5 | 4.45E-05 | 3.60E-04 |