Table 3 Performances of Scuba and of some gene prioritization web tools in the unbiased setting of Börnigen et al. [20]

Genome-wide prioritization methods

Scuba

100

10.55

20.48 ± 23.53

33.3

47.6

78.6

0.80

Candid [44]

100

18.10

27.35 ± 24.62

21.4

33.3

64.3

0.73

Endeavour [39]

100

15.49

21.47 ± 22.37

28.6

38.1

71.4

0.79

Pinta [41]

100

19.03

23.52 ± 23.58

26.2

31.0

71.4

0.77

Candidate set-based prioritization methods

Scuba

100

12.95

23.32 ± 25.46

28.6

45.2

73.8

0.78

Suspects [45]

88.9^a

12.77^a

24.64 ± 26.42^a

33.3^a

33.3^a

63.0^a

0.76^a

ToppGene [40]

97.6

16.80

34.53 ± 35.31

35.7

42.9

52.4

0.66

GeneWanderer-RW [43]

88.1

22.10

29.55 ± 26.28

16.7

26.2

61.9

0.71

Posmed-KS [46]

47.6

31.44

42.07 ± 30.98

4.7

7.1

23.8

0.58

GeneDistiller [38]

97.6

11.11

15.37 ± 13.77

26.2

47.6

78.6

0.85

Endeavour [39]

100

11.16

18.41 ± 21.39

26.2

42.9

90.5

0.82

Pinta [41]

100

18.87

25.23 ± 24.72

28.6

31.0

71.4

0.75