Table 4 Predicted top 10 new genes for Parkinson’s disease by IDLP
From: Prioritizing disease genes with an improved dual label propagation framework
Gene | Score | Evidence of Support |
|---|---|---|
DNAJC13 | 0.7016 | DNAJC13 mutations in Parkinson disease [27]. |
CYP2D6 | 0.5796 | CYP2D6 phenotypes and Parkinson’s disease risk: a meta-analysis [17]. |
DRD4 | 0.5667 | Lack of allelic association of dopamine D4 receptor gene polymorphisms with Parkinson’s disease in a Chinese Population [29]. |
RAB39B | 0.5421 | Loss-of-function mutations in RAB39B are associated with typical early-onset Parkinson disease [15]. |
TRPM7 | 0.3101 | TRPM7 and its role in neurodegenerative diseases [24]. |
SNCB | 0.2342 | Beta-synuclein gene variants and Parkinson’s disease: a preliminary case-control study [4]. |
DCTN1 | 0.1791 | A Novel DCTN1 mutation with late-onset parkinsonism and frontotemporal atrophy [1]. |
ATP6AP2 | 0.1562 | Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS) [14]. |
WDR45 | 0.1415 | - |
PSEN2 | 0.1401 | - |