Fig. 1

a Distributions of conformational diversity for the “large” and the “control” datasets. Distributions of conformational diversity for the “large” dataset measured in RMSD (Å) for the different subgroups AA (transitions from aqueous to aqueous environments in blue), AO (transitions from aqueous to non-aqueous environments in green) and OO (the transition from non-aqueous to non-aqueous environments in red). It is possible to observe that OO pairs have a much lesser conformational diversity than subgroup AA pairs. RMSD averages were 0.97, 0.94 and 0.68 Å for AA, AO and OO, respectively (observed medians: 0.74, 0.77 and 0.51 Å, respectively). P-values for comparisons between OO and AO and OO and AA were << 0.001, while AO and AA distributions showed no significant differences. b The “control” dataset shows the same behaviour than the “large” dataset (1A). c Distributions of conformational diversity for the most populated proteins of the “control” dataset taking into account all the conformer pairs. Distributions of conformational diversity of a representative pool of proteins from the “control” dataset measured in RMSD (Å) for the AA and OO subgroups. Transitions from aqueous to aqueous (AA) environments shown in blue and the transition from non-aqueous to non-aqueous (OO) environments are shown in green