Fig. 2

a Differences in the global ASA for the different subgroups of transitions AA (aqueous-aqueous environments in blue), AO (from aqueous to non-aqueous environments in green) and OO (from non-aqueous to non-aqueous environments in red). Subgroup AO shows the maximum differences evidencing bigger changes between conformers obtained in different solvents. Global ASA average differences were 412.78, 448.66 and 310.76 for AA, AO and OO, respectively (observed medians: 237.67, 257.70 and 162.87, respectively). P-values for global ASA differences comparisons were in all cases < < 0.001. b Differences in the relative ASA for the different transition subgroups AA (aqueous-aqueous environments in blue), AO (from aqueous to non-aqueous environments in green) and OO (the transition from non-aqueous to non-aqueous environments in red). Subgroup AO shows the maximum differences evidencing bigger changes between conformers obtained in different solvents. Relative ASA differences averages were 261.39, 285.51 and 196.33 for AA, AO and OO, respectively (observed medians: 154.30, 165.10 and 103.05, respectively). P-values for relative ASA differences comparisons were in all cases << 0.001