Table 5 Case study: rediscover known drugs for diseases and provide the new mechanism of action of the drugs
From: SemaTyP: a knowledge graph based literature mining method for drug discovery
Disease | Target | Drug | Rank |
|---|---|---|---|
Osteoporosis | col18a1 | Testosterone | 1 |
Osteoporosis | Bone metabolism | ap22408 | 3 |
Cardiac arrhythmia | Actin | Terikalant | 8 |
Cardiovascular disease | Lymphoid cell | Aspirin | 1 |
Cardiovascular disease | slc5a1 | l-nmma | 2 |
Skin allergie | Calprotectin | Mometasone | 1 |
Osteoporosis | Kinase | Calcium-sensing receptor antagonist | 3 |
Anxiety disorder | netrin-1 | Benzodiazepine | 1 |
Anxiety disorder | Urotensin ii | Anxiolytic | 2 |
Anxiety disorder | Platelet activating factor | Buspirone | 4 |
Convulsion | epr | Anidulafungin | 7 |
Graft-versus-host disease | fgf21 | Flavopiridol | 12 |