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Table 5 Case study: rediscover known drugs for diseases and provide the new mechanism of action of the drugs

From: SemaTyP: a knowledge graph based literature mining method for drug discovery

Disease

Target

Drug

Rank

Osteoporosis

col18a1

Testosterone

1

Osteoporosis

Bone metabolism

ap22408

3

Cardiac arrhythmia

Actin

Terikalant

8

Cardiovascular disease

Lymphoid cell

Aspirin

1

Cardiovascular disease

slc5a1

l-nmma

2

Skin allergie

Calprotectin

Mometasone

1

Osteoporosis

Kinase

Calcium-sensing receptor antagonist

3

Anxiety disorder

netrin-1

Benzodiazepine

1

Anxiety disorder

Urotensin ii

Anxiolytic

2

Anxiety disorder

Platelet activating factor

Buspirone

4

Convulsion

epr

Anidulafungin

7

Graft-versus-host disease

fgf21

Flavopiridol

12