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Table 5 The performances of 6 joint tests based on HM27k data GSE37020 and GSE20080

From: Robust joint score tests in the application of DNA methylation data analysis

Test

nSig

nValidation

nTV

pTV(%)

nFV

pFV(%)

JointLRT

4556

2213

1705

77.0

508

23.0

KS

1288

60

47

78.3

13

21.7

AW

1850

262

220

84.0

42

16.0

iAW.Lev

2041

747

666

89.2

81

10.8

iAW.BF

1843

339

296

87.3

43

12.7

iAW.TM

1838

387

342

88.4

45

11.6

  1. nSig: the number of significant CpG sites detected in GSE37020 based on FDR adjusted p-value < 0.05;
  2. nValidation: the number of validated CpG sites in GSE20080 based on unadjusted p-value < 0.05;
  3. nTV: the number of truly validated CpG sites with the same difference directions in means and variances between the two groups;
  4. pTV: \(=\frac {nTV}{nValidation}\), the proportion of significant CpG sites detected in GSE37020 and truly validated in GSE20080;
  5. nFV: the number of falsely validated CpG sites in GSE20080 with inconsistent difference direction in means or variances between the two groups;
  6. pFV: \(=\frac {nFV}{nValidation}\), the proportion of significant CpG sites detected in GSE37020 but falsely validated in GSE20080