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Table 1 Literature validation for natural products, human metabolites and phenotype association

From: A systematic approach to identify therapeutic effects of natural products based on human metabolite information

 

Natural product-human metabolite

Natural product – phenotype

 

Our method

Random

Our method

Random

Co-occurrence

45.09

3.77

3.78

1.47

Jaccard index

1.87 × 10−3

8.21 × 10− 5

1.13 × 10− 3

1.16 × 10− 4

Fisher’s exact testa

266

38

52

6

  1. aThe number of significant associations satisfying the Fisher’s exact test p-value threshold (p-value < 0.001)