Table 7 Top 10 predicted drugs associated with Alzheimer’s disease
From: Predicting drug-disease associations by using similarity constrained matrix factorization
Index | Drug Name | Drug MeSH ID | DrugBank ID | PubChem CID | Score(normalized) | Evidence |
|---|---|---|---|---|---|---|
1 | Nitroprusside | D009599 | DB00325 | 11,963,622 | 1 | N.A. |
2 | Tamoxifen | D013629 | DB00675 | 2,733,526 | 0.7644 | N.A. |
3 | Olanzapine | C076029 | DB00334 | 4585 | 0.7269 | A clinical study [46] |
4 | Sucralfate | D013392 | DB00364 | 70,789,197 | 0.7223 | N.A. |
5 | Levodopa | D007980 | DB01235 | 6047 | 0.6893 | An animal study [47] |
6 | Malondialdehyde | D008315 | DB03057 | 10,964 | 0.6767 | A clinical study [48] |
7 | Progesterone | D011374 | DB00396 | 5994 | 0.6695 | An animal study [49] |
8 | Valproic Acid | D014635 | DB00313 | 3121 | 0.6625 | An animal study [50] |
9 | Scopolamine Hydrobromide | D012601 | DB00747 | 3,000,322 | 0.6522 | N.A. |
10 | Ethanol | D000431 | DB00898 | 702 | 0.6402 | A clinical study [51] |