Fig. 1
From: Performance of epistasis detection methods in semi-simulated GWAS
Score distribution in M0 simulations (no epistasis). Survival function of the scores (SF(score)=P(S>score)) output by each method for various M0 models (continuous line) and theoretical survival functions under H0 (dashed line). For IndOR, fastepi and SHEsisEpi only the top 104 pairs are observed and the survival function therefore reach a plateau for P>104/n pairs =1.19×10−6. For GBOOST a score threshold was set at 30 and therefore reach a plateau for lower scores. For DSS a score −log10(flt DSS ) is returned by the software only for pairs passing a prefilter test as defined in [14], thus overestimating the p-value for small scores