Table 1 Two hundred thirty four disease scenarios considered in the simulations
From: Performance of epistasis detection methods in semi-simulated GWAS
Epistasis model ρ | MAF (f a ,f b ) | LD r2 | Main effect (r a ,r b ) | Interaction ρ | # scenarios |
|---|---|---|---|---|---|
\(M_{0} = \left (\begin {array}{lll} 1 & 1 & 1 \\ 1 & 1 & 1 \\ 1 & 1 & 1\\ \end {array}\right)\) | (0.15,0.15) (0.3,0.3) | 0,0.2,0.5 | (1,1) (1.5,1.5) (1,1.5) | 1 | 18 |
\(M_{1} = \left (\begin {array}{lll} 1 & 1 & 1 \\ 1 & \rho & \rho \\ 1 & \rho & \rho \end {array}\right)\) | (0.15,0.15) (0.3,0.3) | 0,0.2,0.5 | (1,1) (1.5,1.5) (1,1.5) | 2, 3, 5 | 54 |
\(M_{2} = \left (\begin {array}{lll} 1 & 1 & 1 \\ 1 & 1 & 1 \\ 1 & 1 & \rho \\ \end {array}\right)\) | (0.15,0.15) (0.3,0.3) | 0,0.2,0.5 | (1,1) (1.5,1.5) (1,1.5) | 2, 5, 10 | 54 |
\(M_{3} = \left (\begin {array}{lll} 1 & 1 & 1 \\ 1 & \rho & \rho ^{2} \\ 1 & \rho ^{2} & \rho ^{4} \end {array}\right)\) | (0.15,0.15) (0.3,0.3) | 0,0.2,0.5 | (1,1) (1.5,1.5) (1,1.5) | 2, 3, 5 | 54 |
\(M_{4} = \left (\begin {array}{lll} 1 & 1 & 1 \\ 1 & 1 & \rho \\ \rho & \rho & \rho \\ \end {array}\right)\) | (0.15,0.15) (0.3,0.3) | 0,0.2,0.5 | (1,1) (1.5,1.5) (1,1.5) | 2, 3, 5 | 54 |
234 |