Table 2 Smallest epistasis effect ρ detectable with a power 0.8 for each method for various cohort size
From: Performance of epistasis detection methods in semi-simulated GWAS
f=0.15 | f=0.3 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Method | IndOR | DSS | fastepi | GBOOST | SHEsisEpi | IndOR | DSS | fastepi | GBOOST | SHEsisEpi | |
n=n0=n1 | ρ | ||||||||||
500 | > 20 | 8.2 | > 20 | 6.9 | 12.9 | 10.5 | 4.6 | > 20 | 8.1 | 10.5 | r a =1 |
1000 | > 20 | 4.6 | 10.5 | 4.3 | 5.5 | 4.6 | 2.8 | > 20 | 4.6 | 4.6 | r b =1 |
2500 | > 20 | 2.4 | 3.4 | 2.5 | 2.9 | 2.3 | 1.6 | 4.6 | 2.5 | 2.5 | |
5000 | > 20 | 1.7 | 2.5 | 2.0 | 2.1 | 1.8 | 1.4 | 2.6 | 1.9 | 1.8 | |
10000 | > 20 | 1.4 | 1.8 | 1.6 | 1.7 | 1.5 | 1.2 | 1.8 | 1.6 | 1.5 | |
500 | > 20 | 8.7 | > 20 | 6.9 | 15.2 | > 20 | 4.6 | > 20 | 8.7 | 15.2 | r a =1 |
1000 | > 20 | 4.7 | 12.9 | 4.0 | 5.8 | 4.6 | 3.0 | > 20 | 4.6 | 4.7 | r b =1.5 |
2500 | > 20 | 2.5 | 3.7 | 2.5 | 2.8 | 2.4 | 1.6 | 6.3 | 2.6 | 2.5 | |
5000 | > 20 | 1.8 | 2.4 | 1.9 | 2.0 | 1.8 | 1.4 | 2.8 | 1.9 | 1.9 | |
10000 | > 20 | 1.4 | 1.9 | 1.6 | 1.7 | 1.5 | 1.2 | 2.0 | 1.6 | 1.5 | |
500 | > 20 | 5.8 | > 20 | 8.1 | > 20 | > 20 | 3.4 | > 20 | 8.1 | > 20 | r a =1.5 |
1000 | > 20 | 3.2 | 12.9 | 4.0 | 5.8 | 5.8 | 2.0 | > 20 | 4.3 | 5.2 | r b =1.5 |
2500 | > 20 | 1.9 | 4.0 | 2.4 | 2.8 | 2.6 | 1.1 | 8.1 | 2.5 | 2.6 | |
5000 | > 20 | 1.5 | 2.5 | 1.9 | 2.1 | 2.0 | 1.2 | 3.1 | 1.9 | 1.9 | |
10000 | > 20 | 1.2 | 1.9 | 1.5 | 1.7 | 1.6 | 1.1 | 2.0 | 1.5 | 1.5 | |