Fig. 1From: HiCcompare: an R-package for joint normalization and comparison of HI-C datasetsHiCcompare flow chart. Processed Hi-C libraries in the form of sparse upper triangular matrices are the starting data type for HiCcompare. Data is then plotted on the MD plot, and a loess model is fit to remove bias between the libraries. Next, the filtering threshold needs to be determined. Finally, the libraries can be compared for differences and plotted again on the MD plotBack to article page