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Table 3 Performance of five miRNA prediction tools using a miR-181a1/b1 double knock-out experiment

From: miREM: an expectation-maximization approach for prioritizing miRNAs associated with gene-set

Input data

Predictions

 

Datasets

miRNA involved

Gene list

miREM (based on EM) *

ChemiRs

GeneSet2MiRNA **

CORNA#

Sylamer

   

mmu-miR-181a-5p

 

MMU-MIR-181B

  
   

(rank 4 out of 4)

 

(rank 1 out of 9)

  

RNA-seq in mice

miR-181a/b knock out

243

 

Not applicable

 

No result

No result

   

mmu-miR-181b-5p

    
   

(rank 1 out of 4)

    
  1. *Settings: p-value threshold = 0.0001, EM convergence parameter = 0.001, common mappings from 4 or more databases and non-conserved miRNAs not included
  2. **p-value threshold = 0.01
  3. #p-value threshold = 0.05
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BMC Bioinformatics

ISSN: 1471-2105

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