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Table 3 A catalog of functions of histone marks in this study

From: HebbPlot: an intelligent tool for learning and visualizing chromatin mark signatures

Mark

Function

Literature support

H2A.Z

Directional around promoters stretching upstream.

Associated with trascription start sites [39] and promoters [36].

H2AK5ac

Directional around promoters stretching downstream and weakly associated with coding regions of inactive genes.

H2BK5ac

Directional around promoters stretching downstream.

Associated with promoters [36, 47].

H2BK12ac

Directional around promoters stretching downstream.

H2BK120ac

Associated with high-CpG promoters.

Associated with promoters and CpG islands [36].

H3K4ac

Directional around promoters stretching downstream.

Associated with promoters [36].

H3K4me1

Directional around promoters stretching downstream, absent around transcription start sites, and associated with enhancers.

Associated with enhancers [37, 39].

H3K4me2

Directional around promoters stretching downstream and associated with enhancers.

Associated with promoters [74] and enhancers [36].

H3K4me3

Directional around promoters stretching downstream, associated with high-CpG promoters, and associated with enhancers — usually weaker than H3K4me1.

Associated with trascription start sites [39], promoters [36, 37, 74, 75], CpG islands [36], and enhancers [36, 39].

H3K8ac

Weakly associated with coding regions of active genes.

H3K9ac

Directional around promoters stretching downstream, associated with high-CpG promoters, and associated with enhancers.

Associated with promoters [74] and CpG islands [36].

H3K9me3

Weakly associated with coding regions of inactive genes, and very weak/absent from enhancers, and very weak/absent from promoters.

Associate with “repressed regions” [37, 72].

H3K14ac

Directional around promoters stretching downstream and weakly associated with coding regions of inactive genes.

H3K18ac

Directional around promoters stretching downstream.

H3K23ac

Directional around promoters stretching downstream.

H3K27ac

Associated with high-CpG promoters and enhancers.

Associated with trascription start sites [39], promoters [36, 74], high-CpG promoters [47], CpG islands [36], and enhancers [36, 39].

H3K27me3

Weakly associated with coding regions of inactive genes, very weak/absent from enhancers, and very weak/absent from promoters.

“Repressive mark” [37, 72, 75].

H3K36me3

Associated with coding regions and very weak/absent from enhancers.

Associated with and directional around “transcriped gene bodies" [75]; associated with “transcribed regions” [37] and highly expressed genes [72].

H3K79me1

Directional around promoters stretching downstream and associated with coding regions of active genes.

Associated with promoters active in CD4+ [47] and “transcribed regions” [37].

H3K79me2

Directional around promoters stretching downstream and associated with coding regions of active genes.

Associated with “transcribed regions” [37].

H4K12ac

Associated with coding regions of inactive genes — this mark is known in one tissue only.

H4K91ac

Associated with high-CpG promoters.

Associated with promoters [36] and CpG islands [36].