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Fig. 5 | BMC Bioinformatics

Fig. 5

From: An integrated strategy for identifying new targets and inferring the mechanism of action: taking rhein as an example

Fig. 5

Diagrammatic sketch of the idea for network analysis and enrichment analysis. In this diagrammatic sketch, plane a represents the target protein–protein interaction (PPI) of one bioactive compound, targets of which were mapped to a biological network (plane b). In fact, the target extended PPI (EPPI) of this bioactive compound is the network with broken circle in plane b. According to the importance of nodes in the network, plane c was selected from the EPPI via network analysis. The plane d represents the enriched pathway of proteins in plane c. Thus, the potential targets of this bioactive compound in plane d could be considered to be candidate targets

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BMC Bioinformatics

ISSN: 1471-2105

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