Fig. 3

Distribution of peak distances from the nearest TSS. a and b Stack view of all TF ChIP-seq experiments in human a and mouse b ENCODE datasets. For each ChIP-seq, fraction of peaks overlapping a TSS (white), upstream (blue) or downstream (red) of the nearest TSS was computed. Experiments were sorted according to the fraction of the peaks overlapping a TSS, to the exclusion of experiments showing more than 50% of peaks upstream (pink side bar) or downstream (green side bar) of the nearest TSS. c and g A focus on the experiments showing more than 50% of peaks upstream (pink side bar) or downstream (green side bar) of the nearest TSS. c: in human. g in mouse. d MAFK ChIP-seq experiments have few peaks overlapping a TSS. e BRCA1 ChIP-seq experiments have most of their peaks overlapping a TSS. f C-Fos ChIP-seq experiments have a variable fraction of peaks overlapping a TSS. h Fraction of peaks overlapping a TSS was compared between mouse and human for each TF present in both datasets. x-axis: fraction of peaks overlapping a TSS in human. y-axis: fraction of peaks overlapping a TSS in mouse. Grey cross: Range of the Median Absolute Deviation (MAD) of the fraction of peaks overlapping a TSS in cases where several experiments where done for a given TF. Blue line: linear regression. Doted red line: x = y line. cor: Pearson correlation coefficient