Fig. 1

Valection Candidate-Selection Strategies. a A hypothetical scenario where we have results from three callers available. Each call is represented using a dot. SNV calls that are shared by multiple callers are represented with matching dot colours. b The ‘random rows’ method where all unique calls across all callers are sampled from with equal probability. c The ‘directed-sampling’ method where a ‘call overlap-by-caller’ matrix is constructed and the selection budget is distributed equally across all cells. d The ‘equal per caller’ method where the selection budget is distributed evenly across all callers. e The ‘equal per overlap’ method where the selection budget is distributed evenly across all levels of overlap (i.e. call recurrence across callers). f The ‘increasing with overlap’ method where the selection budget is distributed across overlap levels in proportion to the level of overlap. g The ‘decreasing with overlap’ method where the selection budget is distributed across overlap levels in inverse proportion to the level of overlap