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Fig. 3 | BMC Bioinformatics

Fig. 3

From: 3D Network exploration and visualisation for lifespan data

Fig. 3

LO Network Visualisation Techniques. Techniques for the integrated visualisation of lifespan experiments as networks. LOs and AFs are represented by nodes. Node colour and size are used to speed-up the lookup of node properties by visual perception. a DirectNeighbourhood: For focusing on a specific AF only the direct neighbourhood of the AF is visualised. This includes the AF in the focus (AF1), all directly linked LOs (LO1,LO2,LO3), and all other AFs linked directly to these LOs (AF2,AF3). b Complete Neighbourhood: For a more comprehensive view the direct neighbourhood network is extended iteratively by including further AFs (AF4,AF5) that were observed together with the neighbours (AF2,AF3) of the AF in the focus (AF1) and their LOs (LO4,LO5,LO6,LO7,LO8). c Augmentation via Annotation Nodes: Additional information for AF and LO nodes is integrated by annotation nodes (ANN1, ANN2). They provide the information directly in a visual form and result in a reorganisation of the network layout. d Data Transfer between nodes: The data transfer between nodes can help to reduce the complexity of a network by removing nodes while retaining some of their data. Here all 8 LOs were removed after transforming the directions of the lifespan changes into a new colour scheme for the 5 AFs. e Multi-species: A special case of essential augmentation with species nodes for networks focusing on AFs that can be linked to multiple species, like chemical compounds. For a clearer view the AFs are linked only indirectly to the species nodes by the LOs: AF1 to SP1 via LO1, to SP2 via LO2, and to SP3 via LO3 and LO4;AF2 to SP1 via LO1;AF3 to SP3 via LO4. Color scheme (a, b, c, e): AF, LO - increased lifespan, LO - decreased lifespan, annotation, species Color scheme (d): annotation, AF - linked only to LOs with increased lifespan, AF - linked to LOs with highly mixed lifespan changes (increased and decreased >20%)

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