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Table 2 Compound–gene interactions presented in Table 1 that significantly overlap with interactions described in two datasets

From: Drug candidate identification based on gene expression of treated cells using tensor decomposition-based unsupervised feature extraction for large-scale data

Compounds

(1)

(2)

(3)

(4)

(5)

(6)

(7)

(8)

(9)

(10)

(11)

(12)

(13)

Dabrafenib

            

             

Dinaciclib

      

       

CGP-60474

  

 

  

   

×

×

×

×

×

 

×

  

×

LDN-193189

   

       

 

   

       

OTSSP167

      

 

 

       

 

 

WZ-3105

 

 

 

  

  

 

 

  

AT-7519

   

 

 

  

 
    

 

 

  

 

BMS-387032

   

 

 

    
    

 

 

    

JNK-9L

        

    
         

    

Alvocidib

  

    
 

  

    

GSK-2126458

      

    

 
       

    

 

NVP-BEZ235

      

    

 
       

×

    

×

 

Torin-2

      

×

    

×

 
       

    

 

NVP-BGT226

    

  

  

 
     

  

  

 

QL-XII-47

            
 

            

Celastrol

            
 

            

A443654

 

 

         
  

 

         

NVP-AUY922

    

×

       
     

       

Radicicol

     

       
      

       
  1. For each compound in the table, the upper row: the drug2gene.com dataset was used for comparisons [69], the lower row: the DSigDB dataset was used for comparisons [70]. Columns represent cell lines used in the analysis: (1) BT20, (2) HS578T, (3) MCF10A, (4) MCF7, (5) MDAMB231, (6) SKBR3, (7) A549, (8) HCC515, (9) HA1E, (10) HEPG2, (11) HT29, (12) PC3, (13) A375. : a significant overlap between the datasets (P<0.05); ×: no significant overlap between the datasets; —: no data; blank: no significant dose–response relation was identified. The confusion matrix and a full list of commonly selected genes are available in Additional file 3