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Table 2 Compound–gene interactions presented in Table 1 that significantly overlap with interactions described in two datasets

From: Drug candidate identification based on gene expression of treated cells using tensor decomposition-based unsupervised feature extraction for large-scale data

Compounds (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12) (13)
Dabrafenib             
             
Dinaciclib       
       
CGP-60474        
    × × × × ×   ×    ×
LDN-193189            
             
OTSSP167         
           
WZ-3105      
         
AT-7519             
             
BMS-387032             
             
JNK-9L              
              
Alvocidib        
       
GSK-2126458            
            
NVP-BEZ235              
        ×      ×  
Torin-2        ×      ×  
              
NVP-BGT226          
          
QL-XII-47             
             
Celastrol             
             
A443654              
              
NVP-AUY922      ×        
            
Radicicol              
             
  1. For each compound in the table, the upper row: the drug2gene.com dataset was used for comparisons [69], the lower row: the DSigDB dataset was used for comparisons [70]. Columns represent cell lines used in the analysis: (1) BT20, (2) HS578T, (3) MCF10A, (4) MCF7, (5) MDAMB231, (6) SKBR3, (7) A549, (8) HCC515, (9) HA1E, (10) HEPG2, (11) HT29, (12) PC3, (13) A375. : a significant overlap between the datasets (P<0.05); ×: no significant overlap between the datasets; —: no data; blank: no significant dose–response relation was identified. The confusion matrix and a full list of commonly selected genes are available in Additional file 3