Fig. 6

Switch genes and their negative nearest neighbors for Schulte et al. GBM dataset [25]. a Bar plots representing the sorted logarithmic fold-change (GSf and tumors versus conventional cell lines) for switch genes (left) and their negative nearest neighbors (right). b Pie charts representing the classification of switch genes according with their molecular type. c Heatmap representing the z-score normalized expression level of switch genes grouped according their enriched KEGG pathways. d Network reporting the negative nearest neighbors of the switch genes, where the core set of the well-known stemness genes is highlighted in magenta. e Word-cloud representing the biological processes (GO terms) over-represented in the list of the negative nearest neighbors