Table 7 Gene characteristics significant in stepwise best subset multiple linear regression model for the prediction of the number of missense mutations
From: Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples
Predictor | T-test | P-value | Beta (ß) |
|---|---|---|---|
Number of silent mutations in the gene | 136.47 | 1.8 × 10− 376 | 0.76 |
Replication time | −7.74 | 1.0 × 10−14 | −0.03 |
Percentage of “C” | − 7.64 | 2.4 × 10− 14 | − 0.06 |
Nucleotide diversity | −6.65 | 3.1 × 10−11 | − 0.03 |
Percentage of “G” | − 6.14 | 8.2 × 10−10 | − 0.03 |
“reptime” from MutsigCV | 5.24 | 1.7 × 10− 7 | 0.02 |
Evolutionary conservation | −4.57 | 4.9 × 10− 6 | − 0.01 |
Percentage of “CpGs” | − 3.62 | 3.0 × 10− 4 | − 0.02 |
“expr” from MutsigCV | 2.79 | 5.3 × 10− 3 | 0.01 |
Number of potential sites for missense mutations | 2.57 | 1.0 × 10−2 | 0.42 |