Table 9 Gene characteristics significant in stepwise best subset multiple linear regression model for frameshift mutations
From: Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples
Predictor | T-test | P-value | Beta (ß) |
|---|---|---|---|
Gene size in nucleotides | 50.93 | 3.34 × 10− 218 | 0.38 |
Nucleotide diversity | −10.69 | 5.56 × 10− 26 | − 0.1 |
Number of silent mutations in the gene | 6.86 | 5.65 × 10− 09 | 0.1 |
Percentage of “C” | 5.26 | 3.84 × 10−7 | 0.09 |
Percentage of “A” | 5.16 | 6.52 × 10− 7 | 0.09 |
Gene expression in CCLE cancer cell lines | 4.21 | 5.64 × 10−5 | 0.03 |
Percentage of “CpGs” | − 4.1 | 8.84 × 10− 5 | − 0.06 |
Percentage of “G” | − 3.62 | 5.52 × 10− 4 | − 0.04 |
“hic” from MutsigCV | 2.25 | 3.14 × 10− 2 | 0.01 |
Evolutionary conservation | 2.09 | 4.42 × 10− 2 | 0.01 |