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Fig. 1 | BMC Bioinformatics

Fig. 1

From: COMBImage: a modular parallel processing framework for pairwise drug combination analysis that quantifies temporal changes in label-free video microscopy movies

Fig. 1

COMBImage Case Study. Selected results in checkerboard style screens produced by COMBO-V, COMBO-M and COMBO-C, for normal astrocytes (first row), sensitive GIC clone (second row) and resistant GIC clone (third row), when SAHA was combined with CPD-1, an investigational cytotoxic compound. The information shown for a particular combination concentration patch is as follows. COMBO-V: cell viability, from purple showing full cell survival (100%) to yellow showing zero cell survival (0%). COMBO-M: relative difference from the top 5% of corresponding natural/untreated morphological effects, from purple being −100% to yellow being 100%. COMBO-C: growth curves of treated (red) and untreated (black) GIC clones. All growth curves are expressed with respect to the first time point

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BMC Bioinformatics

ISSN: 1471-2105

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