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Fig. 4 | BMC Bioinformatics

Fig. 4

From: COMBImage: a modular parallel processing framework for pairwise drug combination analysis that quantifies temporal changes in label-free video microscopy movies

Fig. 4

COMBO-M Flowchart. (1) Image datastore is selected by the user; (2) Image quality control, back up and foreground segmentation; (3) MapReduce TEM extraction; (4) DTEM extraction; (5) DTEM ranking based on null hypothesis testing; (6) Extraction of raw results in TXT file format; (7) Specification file is selected by the user; (8) Deployment of the custom experimental format; (9) Global checkerboard style screens as heatmaps in EPS file format. Modules (3) - (6) are executed for all parameter pairs (r,b) per decreasing time interval t, starting with all time points and ending up to only the last time point. The optimum pair for each decreasing time interval t, is the one that maximizes the number of detections

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BMC Bioinformatics

ISSN: 1471-2105

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