Table 8 Mapping of the datasets to Pfam domains
dataset | number of unique Pfam domains | number of variants with a Pfam domain | % variants with a Pfam domain of total number of variants in dataset | no. of variants mapped to a UniProt sequence | % variants with a Pfam domain of number of variants mapped to UniProt | KS statistica |
|---|---|---|---|---|---|---|
DS1 | 5213 | 148,681 | 33.34 | 378,706 | 39.26 | 0.25 (< 10− 4) |
DS2 | 2065 | 7307 | 30.87 | 18,660 | 39.16 | 0.64 (< 10− 4) |
DS3 | 794 | 14,228 | 73.59 | 19,318 | 73.65 | 0.86 (< 10− 4) |
DS4 | 1954 | 6589 | 33.86 | 15,880 | 41.49 | 0.66 (< 10− 4) |
DS5 | 742 | 10,997 | 75.27 | 14,597 | 75.34 | 0.87 (< 10− 4) |
DS6 | 1898 | 5293 | 30.03 | 13,811 | 38.32 | 0.67 (< 10− 4) |
DS7 | 775 | 12,842 | 73.28 | 17,514 | 73.32 | 0.86 (< 10− 4) |
DS8 | 1810 | 4833 | 33.00 | 11,847 | 40.80 | 0.68 (< 10−4) |
DS9 | 727 | 9796 | 74.80 | 13,096 | 74.80 | 0.87 (< 10− 4) |
DS10 | 1632 | 4396 | 33.65 | 10,882 | 40.40 | 0.72 (< 10−4) |
DS11 | 668 | 9641 | 76.61 | 12,584 | 76.61 | 0.88 (< 10− 4) |
DS12 | 147 | 579 | 36.07 | 1288 | 44.95 | 0.97 (< 10−4) |
DS13 | 80 | 897 | 68.95 | 1301 | 68.95 | 0.99 (< 10− 4) |
DS14 | 1197 | 2656 | 30.66 | 7185 | 36.97 | 0.79 (< 10− 4) |
DS15 | 551 | 5619 | 78.85 | 7151 | 80.31 | 0.90 (< 10− 4) |
DS16 | 116 | 354 | 33.62 | 848 | 42.22 | 0.98 (< 10−4) |
DS17 | 64 | 526 | 70.04 | 751 | 70.04 | 0.99 (< 10−4) |
DS18 | 1265 | 7190 | 44.66 | 12,056 | 59.64 | 0.78 (< 10−4) |
DS19 | 1172 | 4859 | 47.33 | 10,154 | 47.85 | 0.80 (< 10−4) |
DS20 | 1046 | 4818 | 54.44 | 8662 | 55.62 | 0.82 (< 10− 4) |
DS21 | 2301 | 20,415 | 50.55 | 39,735 | 51.38 | 0.60 (< 10− 4) |
DS22 | 2090 | 7727 | 36.53 | 21,151 | 36.53 | 0.64 (< 10−4) |
DS23 | 1073 | 16,309 | 73.48 | 22,196 | 73.48 | 0.81 (< 10− 4) |
DS24 | 3325 | 41,997 | 55.94 | 75,042 | 55.96 | 0.61 (< 10−4) |