Fig. 6

Outline flow chart for building a vector of a drug-disease pair.a represents interactions between drugs and a disease. We determined the type and weight for each target gene-disease gene pair by finding the shortest path from a target gene to a disease gene. b shows the process of building regulation vector using regulation values and interaction types for target gene-disease gene pairs. The value for each target gene-disease gene pair was multiplied by − 1 when the type of interaction between a drug and the target gene was inhibition. c shows a matrix consisting of drug-disease vectors for a disease. The size of each vector for a disease was determined by the number of its disease genes, and a group of vectors could be expressed as a matrix