Predicting tumor cell line response to drug pairs with deep learning

BMC Bioinformatics

Table 1 Cross validation results from feature combination experiments

Molecular features	Drug features	MSE	MAE	R ²
Baseline	Baseline	0.5253	0.5709	-1.001
One-hot encoding	One-hot encoding	0.2448	0.3997	0.1269
Gene expression	One-hot encoding	0.2447	0.3999	0.1272
Gene expression	500-dimensional noise	0.2450	0.4008	0.1271
One-hot encoding	Dragon7 descriptors	0.0292	0.1086	0.8892
Proteome	Dragon7 descriptors	0.0303	0.1117	0.8844
microRNA	Dragon7 descriptors	0.0275	0.1050	0.8952
Gene expression	Dragon7 descriptors	0.0180	0.0906	0.9364
Gene expression, microRNA, proteome	Dragon7 descriptors	0.0158	0.0833	0.9440

ISSN: 1471-2105