Fig. 1

Rough Set Theory Rule Generation. A) Venn diagram of active and inactive peptides. A rule (R₁) is the intersection of conditions (C₁and C₂). Each rule must be selective for either active or inactive peptides. The minimum accuracy allowed for a rule is a user-defined parameter α. B) Venn diagram showing multiple rules as the intersection of conditions in 2-D space. The selection of conditions that lead to rules is a feature selection process that chooses the most relevant conditions to describe the physicochemical boundaries. A rule set is the collection of all rules describing the boundaries for either activity or inactivity